目前主持国家自然科学基金2项、国家重点研发计划子课题1项，参与国家重点研发计划2项，主持横向课题多项。入选北京市科协2020-2022年度青年人才托举工程、中国农业大学青年人才培育计划和动物科学技术学院青年英才A类计划。获颐和青年奖和MichaelG.DeGrooteFellowshipAwards。担任Frontiersinnutrition杂志associateeditor和animalresearchandonehealth杂志编委。
欢迎有科研热情的学生参与我的研究，也欢迎社会各界的科研合作。请联系18519892836或wangbo123@cau.edu.cn，WechatID：hellowangbo。
部分科研内容：
Thepesticidechlorpyrifospromotesobesitybyinhibitingdiet-inducedthermogenesisinbrownadiposetissue
MaternalsupplementationofvitaminApromotesangiogenesisandbeigeadipogenesis,whichprotectsoffspringfromhighfat-inducedobesity.
RetinoicacidinhibitswhiteadipogenesisbydisruptingGADD45AmediatedZfp423DNAdemethylation
RetinoicacidinduceswhiteadiposetissuebrowningbyincreasingadiposevascularityandinducingbeigeadipogenesisofPDGFRα+adiposeprogenitors
Increasingadipocytenumberandreducingadipocytesize:theroleofretinoidsinadiposetissuedevelopmentandmetabolism
部分论文：
Wang,B.andDu,M.,2023.Increasingadipocytenumberandreducingadipocytesize:theroleofretinoidsinadiposetissuedevelopmentandmetabolism.CriticalReviewsinFoodScienceandNutrition:1-18.
Chen,X.,Zhao,J.,Li,Q.,Li,X.,Wang,Y.,Wang,B*.andZhao,J*.,2023.VitaminAinjectionatbirthimprovesmusclegrowthinlambs.AnimalNutrition.
Xu,Y.-X.,B.Wang,J.-N.Jing,R.Ma,Y.-H.Luo,X.Li,Z.Yan,Y.-J.Liu,L.Gao,andY.-L.Ren.2023.Whole-bodyadiposetissuemulti-omicanalysesinsheeprevealmolecularmechanismsunderlyinglocaladaptationtoextremeenvironments.CommunicationsBiology6:159.
Ayansola,H.,Y.Luo,Y.Wan,X.Yu,J.Lei,K.Yu,C.Liao,Y.Guo,B.Zhang,andB.Wang.2023.Restrictedfeedingregimensimprovewhitestripingassociatedmusculardefectsinbroilerchickens.AnimalNutrition12:128-137.
Wang,B.,andG.R.Steinberg.2022.Environmentaltoxicants,brownadiposetissue,andpotentiallinkstoobesityandmetabolicdisease.CurrentOpinioninPharmacology67:102314.
BoWang,EvangeliaTsakiridis,ShumanZhang,AndreaLlanos,EricDejardins,JulianYabut,AlexanderGreen,EmilyDay,BrennanSmith,JamesLally,JianhanWu,MrAmogelangRaphenya,KrishnaSrinivasan,AndrewMcArthur,ShingoKajimura,JagdishSureshPatel,MichaelWade,KatherineMorrison,AlisonHolloway,GregorySteinberg.2021.Thepesticidechlorpyrifospromotesobesitybyinhibitingdiet-inducedthermogenesisinbrownadiposetissue.NatureCommunications12,5163.
Wang,Y.,Y.Wu,J.Chen,X.Guo,L.Yan,Y.Guo,B.Wang*,andJ.Yuan.2021.Thedurationoffoodwithdrawalaffectstheintestinalstructure,nutrientsabsorption,andutilizationinbroilerchicken.FASEBJ35(1):e21178.
Li,S.,J.You,Z.Wang,Y.Liu,B.Wang,M.Du,andT.Zou.2021.Curcuminalleviateshigh-fatdiet-inducedhepaticsteatosisandobesityinassociationwithmodulationofgutmicrobiotainmice.FoodRes.Int.143:110270.
Zhao,L.,J.S.Son,B.Wang,Q.Tian,Y.Chen,X.Liu,J.M.deAvila,M.-J.Zhu,andM.Du.2020.Retinoicacidsignallinginfibro/adipogenicprogenitorsrobustlyenhancesmuscleregeneration.EBioMedicine60:103020.
Ayansola,H.,C.Liao,Y.Dong,X.Yu,B.Zhang,andB.Wang*.2020.Prospectofearlyvasculartoneandsatellitecellmodulationsonwhitestripingmusclemyopathy.Poult.Sci.
WangB,FuX,LiangXW,WangZX,ZhaoL,TianQY,ZhaoJX,GomezNA,TrombettaSC,AvilaJM,ZhuMJ,andDuM.RetinoicacidinduceswhiteadiposetissuebrowningbyincreasingadiposevascularityandinducingbeigeadipogenesisofPDGFRα+adiposeprogenitors.Celldiscovery,2017,3:17036.
WangB,WangZX,AvilaJM,ZhuMJ,ZhangFY,GomezNA,ZhaoL,TianQY,ZhaoJX,MaricelliJ,ZhangH,RodgersBDandDuM.Moderatealcoholintakeinducesthermogenicbrown/beigeadipocyteformationviaelevatingretinoicacidsignaling.FASEBJ,2017Vol.31.
WangB,FuX,ZhuMJ,DuM.RetinoicacidinhibitswhiteadipogenesisbydisruptingGADD45AmediatedZfp423DNAdemethylation.Journalofmolecularcellbiology,2017,9(4):338-349.
WangB,FuX,LiangXW,WangZX,YangQY,ZouTD,NieW,ZhaoJX,GaoPF,ZhuMJ,AvilaJM,MaricelliJ,RodgersBM,andDuM.MaternalRetinoidsIncreasePDGFRα+ProgenitorPopulationandBeigeAdipogenesisinProgenybyStimulatingVascularDevelopment.EbioMedicine,2017,18:288-299.
WangB,ZhangFY,WangZX,ZhangH,DuM.Alcoholaggravatecancerinducedcachexiaviainducingadiposebrowningandskeletalmuscleatrophy.Oncotarget,2017.
WangB,MinZ,YuanJM,ZhangBK,GuoYM.Effectsofdietarytryptophanandstockingdensityontheperformance,meatquality,andmetabolicstatusofbroilers.JournalofAnimalScienceandBiotechnology2014,5(1):44
WangB,YangG,LiangXW,ZhuMJ,andDuM.Grapeseedextractpreventsskeletalmusclewastingininterleukin10knockoutmice.BMC-ComplementaryandAlternativeMedicine,2014,(14):162.
WangB.,Q.Yang,C.L.Harris,M.L.Nelson,J.R.Busboom,M.J.Zhu,andDuM.Nutrigenomicregulationofaidposetissuedevelopment–roleofretinoicacid.MeatScience,2016,120:100-106.
WangB,NieW,FuX,deAvilaJM,MaY,ZhuMJ,MaquivarM,ParishSM,BusboomJR,NelsonML,DuM:NeonatalvitaminAinjectionpromotescattlemusclegrowthandincreasesoxidativemusclefibers.JournalofAnimalScienceandBiotechnology2018,9:82.
Wang,B.,Qu,Y.,Wang,Y.,Ma,Y.,Xu,C.,Li,F.,Liu,C.,Lu,X.,Wang,B.,Xiu,P.andGao,Y.,2019.TripletMaleLambsAreMoreSusceptiblethanTwinstoDietarySoybeanOil–InducedFattyLiver.TheJournalofnutrition,149(6),pp.989-995.
C.L.Harris#,B.Wang#,J.M.Deavila,J.R.Busboom,M.Maquivar,S.M.Parish,B.McCann,M.L.Nelson,M.Du,VitaminAadministrationatbirthpromotescalfgrowthandmarblingfatdevelopmentinAngusbeefcattle.Journalofanimalscienceandbiotechnology,2018.(co-firstauthor)
MaYN#,WangB#,WangZX,ZhuMJ,DuM.Adipogenicdifferentiationofbovinestromalvascularcellsinorganoidculture.Animal,2018.(co-firstauthor)
WangB,MinZ,YuanJM.Apparentilealdigestibletryptophanrequirementsof22-to42-day-oldbroilerchicks.TheJournalofAppliedPoultryResearch,2015:pfv061.
MaricelliJA,BishawYM,WangB,DuMandRodgersBD.Systemicsmad7genetherapyincreasesstriatedmusclemassandenhancesexercisecapacityinadose-dependentmanner.Humangenetherapy,2017.
FuX,YangQY,WangB,ZhaoJX,ZhuMJ,ParishSM,DuM.ReducedsatellitecelldensityandmyogenesisinWagyucomparedwithAnguscattleasapossibleexplanationofitshighmarbling.Animal,2017.
YangQ,LiangX,SunX,ZhangL,FuX,RogersCJ,BerimA,ZhangS,WangS,WangB,ForetzM,ViolletB,GangDR,RodgersBD,ZhuMJ,DuM.AMPK/α-ketoglutarateaxisdynamicallymediatesDNAdemethylationinthePrdm16promoterandbrownadipogenesis.Cellmetabolism.2016.
ZouT,ChenD,YangQ,WangB,ZhuMJ,NathanielszPW,DuM:Resveratrolsupplementationtohighfatdiet‐fedpregnantmicepromotesbrownandbeigeadipocytedevelopmentandpreventsobesityinmaleoffspring.TheJournalofphysiology.2017.
Liang,X.,YangY,FuX,RogersCJ,WangB,PanH,ZhuMJ,NathanielszPW,andDuM.Maternalobesityepigeneticallyaltersvisceralfatprogenitorcellpropertiesinmaleoffspringmice.TheJournalofPhysiology,2016,594(15):4453-4466.
DuM,WangB,FuX,YangQ,ZhuMJ.Fetalprogramminginmeatproduction.Meatscience,2015(109):40-47.(IF:3.1)
HuangC,WangB,MinZ,YuanJM.Dietaryinclusionlevelandtimeeffectsoftaurineonbroilerperformance,meatquality,oxidativestatusandmuscletaurinecontent.Britishpoultryscience,2014,55(5),598-604.
YuanJM,WangB,HuangZ,FanY,HuangC,HouZ.Comparisonsofeggqualitytraits,eggweightlossandhatchabilitybetweenstripedandnormalduckeggs.BritishPoultryScience54.2(2013):265-269.
Xing,T.,Y.Kang,X.Xu,B.Wang,M.Du,andM.J.Zhu*.Raspberrysupplementationimprovesinsulinsignalingandpromotesbrown-likeadipocytedevelopmentinwhiteadiposetissueofobesemice.MolecularNutritionandFoodResearch,2018.
ZouT,WangB,YangQ,deAvilaJM,ZhuMJ,YouJ,ChenD,DuM.Raspberrypromotesbrownandbeigeadipocytedevelopmentinmicefedhigh-fatdietthroughactivationofAMP-activatedproteinkinase(AMPK)α1.TheJournalofNutritionalBiochemistry.2018.
ZhaoL,ZouTD,GomezN,WangB,ZhuMJ,andMinD.Raspberryalleviatesobesity-inducedinflammationandinsulinresistanceinskeletalmusclethroughactivationofAMP-activatedproteinkinase(AMPK)α1.Nutrition&Diabetes,2018.
Zou,T.,Wang,B.,Li,S.,Liu,Y.andYou,J.,2020.Dietaryapplepolyphenolspromotefatbrowninginhigh-fatdiet-inducedobesemicethroughactivationofadenosinemonophosphate-activatedproteinkinaseα.JournaloftheScienceofFoodandAgriculture.
Yabut,J.M.,Desjardins,E.M.,Chan,E.J.,Day,E.A.,Leroux,J.M.,Wang,B.,Crane,E.D.,Wong,W.,Morrison,K.M.,Crane,J.D.andKhan,W.I.,2020.Geneticdeletionofmastcellserotoninsynthesispreventsthedevelopmentofobesityandinsulinresistance.Naturecommunications,11.
Zhao,L.,Wang,B.,Gomez,N.A.,deAvila,J.M.,Zhu,M.J.andDu,M.,2020.Evenalowdoseoftamoxifenprofoundlyinducesadiposetissuebrowninginfemalemice.InternationalJournalofObesity,44(1),pp.226-234.
Zou,T.,Kang,Y.,Wang,B.,deAvila,J.M.,You,J.,Zhu,M.J.andDu,M.,2019.Raspberrysupplementationreduceslipidaccumulationandimprovesinsulinsensitivityinskeletalmuscleofmicefedahigh-fatdiet.JournalofFunctionalFoods,63,p.103572.
Tian,Q.,Zhao,J.,Yang,Q.,Wang,B.,Deavila,J.M.,Zhu,M.J.andDu,M.,2019.Dietaryalpha‐ketoglutaratepromotesbeigeadipogenesisandpreventsobesityinmiddle‐agedmice.Agingcell,p.e13059.