1、四、关于论文的总体审查意见1.Thisisacarefullydonestudyandthefindingsareofconsiderableinterest.Afewminorrevisionarelistbelow.2.Thisisawell-writtenpapercontaininginterestingresultswhichmeritpublication.Forthebenefitofthereader,however,anumberofpointsneedclarifyingandce
2、rtainstatementsrequirefurtherjustification.Therearegivenbelow.3.Althoughtheseobservationareinteresting,theyareratherlimitedanddonotadvanceourknowledgeofthesubjectsufficientlytowarrantpublicationinPNAS.Wesuggestthattheauthorstrysubmittingtheirfindingstospecia
3、listjournalsuchas-4.Althoughthispaperisgood,itwouldbeeverbetterifsomeextradatawereadded.5.Thismanuscriptisnotsuitableforpublicationinthejournalof-becausethemainobservationitdescribewasreported3yearsagoinareputablejournalof-.6.Pleaseasksomeonefamil
4、iarwithEnglishlanguagetohelpyourewritethispaper.Asyouwillsee,Ihavemadesomecorrectionatthebeginningofthepaperwheresomesyntaxisnotsatisfactory.7.WefeelthatthispotentiallyinterestingstudyhasbeenmarredbyaninabilitytocommunicatethefindingcorrectlyinEngli
5、shandshouldliketosuggestthattheauthorsseektheadviceofsomeonewithagoodknowledgeofEnglish,preferablenativespeaker.8.Thewordingandstyleofsomesection,particularlythoseconcerningHPLC,needcarefulediting.AttentionshouldbepaidtothewordingofthosepartsoftheDis
6、cussionofandSummarywhichhavebeenunderlined.9.PreliminaryexperimentsonlyhavebeendoneandwithexceptionofthatsummarizedinTable2,nonehasbeenrepeated.Thisisclearlyunsatisfactory,particularlywhenthereissomuchvariationbetweenassays.10.Theconditionofincubationarep
7、oorlydefined.WhatisthetemperatureWereantibodyused五、给编辑的回信1.Inreplytotherefereesmaincriticismofpossibletosaythat-OneminorpointraisedbytherefereeconcernsoftheextracompositionofthereactionmixtureinFigure1.Thishasnowbeencorrected.Furtherminorchangeshadbe
8、enmadeonpage3,paragraph1(line3-8)and2(line6-11).Thesedonotaffectourinterpretationoftheresult.2.Ihavereadtherefereescommentsverycarefinnyiandtbotthepaperhasbeenrejectedonthesolegroundsthatitlaketoxicitydata.IadmitthatIdidnotincludeatoxicitytablein
9、myarticlealthoughperhapsIshouldhavedone.Thiswasforthesakeofbrevityratherthananerrororomission.3.Thankyouforyourletterofandfortherefereescommentsconcerningourmanuscriptentitledhavestudiedtheircommentscarefullyandhavemadecorrectionwhichwehopemeetwiththe
10、irapproval.4.Ienclosedarevisedmanuscriptwhichincludesareportofadditionalexperimentsdoneattherefereesuggestion.Youwillseethatouroriginalfindingsareconfirmed.5.Wearesendingtherevisedmanuscriptaccordingtothecommentsofthereviewers.Revisedportionareunderlined
11、inred.6.Wefoundtherefereescommentsmosthelpfulandhaverevisedthemanuscript7.Wearepleasedtonotethefavorablecommentsofreviewersintheiropeningsentence.8.Thankyouforyourletter.IamverypleasedtolearnthatourmanuscriptisacceptableforpublicationinCancerResearch
12、withminorrevision.9.Wehavethereforecompletedafurtherseriesofexperiments,theresultofwhicharesummarizedinTable5.Fromthisweconcludethatintrinsicfactorisnotaccount.10.Wedeletedtherelevantpassagesincetheyarenotessentialtothecontentsofthepaper11.Ifeelthatt
13、hereviewerscommentsconcerningFigures1and2resultfromamisinterpretationofthedata.12.Wewouldhaveincludeanon-proteininhibitorinoursystem,asacontrol,ifonehadbeenavailable.13.WeprefertoretaintheuseofTable4forreasonsthatitshouldbeclearfromthenewparagraph
14、insertedattheendoftheResultssection.14.Althoughreviewerdoesnotconsideritisimportanttomeasurethetemperatureofthecells,weconsideritessential.15.Therunningtitlehasbeenchangedto“”.16.TheMaterialsandMethodssectionnowincludesdetailsformeasuringuptakeofisotope
16、actiononchromosomehasbeenincluded(page16,paragraph2).19.Weincludedanewsetofphotographswithbetterdefinitionthanthoseoriginallysubmittedandtowhichascalehasbeenadded.20.Followingthesuggestionofthereferees,wehaveredrawFigure3and4.21.Twofurtherpapers,publis
17、hedsinceouroriginalsubmission,havebeenaddedtothetextandReferencesection.Theseare:22.Weshouldliketothanktherefereesfortheirhelpfulcommentsandhopethatwehavenowproducedamorebalanceandbetteraccountofourwork.Wetrustthattherevisedmanuscriptisacceptableforpublication.23.Igreatlyappreciatebothyourhelpandthatoftherefereesconcerningimprovementtothispaper.Ihopethattherevisedmanuscript